I am sorry but Digi does not have listed settings needed for an Amazon Echo. My best guess is that you will need to set the ZS to 2. As for the Encryption options, that will dependent on what Zigbee standard the Echo works on. I would expect Amazon to be able to tell you want options are needed and what Key if any is needed.
You will want to write your app so that you are using the proper End points for the desired target end device. IE wall switch, light, Etc.
IF you are using an external processor, then set the AP to 1 and AO to enable bits 2 and 3.